Fruit and vegetable mixtures for health-promoting colored extruded snacks

Diet-related non-communicable diseases have an impact on sustainable development and have greatly influenced mortality worldwide, even nowadays, where they regained a greater relevance with COVID-19 pandemic emergence. Food habits and immunity have been closely related, and technological adaptions to produce healthier snacks are now on the global agenda of the food industry. As naturally functional raw materials, fruit and vegetables (F&V) effectively meet the high nutritional value and sensory appeal necessary to snacks design. This work aimed to harness the potential of such resources, including both native and introduced F&V species that confer visually attractive color to cold processed extrudates. The performance of different F&V processing methods was tested, for final blending with hydrocolloids resulting in sugarless confectionery-like extruded snacks. Liquid and dry milling of F&V yielded colorful pigment-rich ingredients, whose physical characteristics differed in terms of extraction efficiency, water activity, and moisture, with associated technological process advantages or handicaps. Formulas with different hydrocolloids were tested, and the one with the highest sensory acceptability was reported. © 2023 International Society for Horticultural Science. All rights reserved.

Utilization of pumpkin, pumpkin powders, extracts, isolates, purified bioactives and pumpkin based functional food products, a key strategy to improve health in current post COVID 19 period, an updated review

Progression of today's world has been given setback due to the adversity of a novel, viral and deadly outbreak COVID 19, which raised the concerns of the scientists, researchers and health related officials about the inherent and adaptive immune system of the living body and its relation with healthy diet balanced with pharma foods. Choice of right food can help to build and boost adaptive immunity and pumpkin due to excellent profile of functional and nutraceutical constituents must be the part of both infected and non-infected person's daily diet. Vitamins, minerals, phenolic acids, essential oils, peptides, carotenoids and polysaccharides present in pumpkin could accommodate the prevailing deficiencies in the body to fought against the pathogens. Pumpkins are well equipped with nutraceuticals and functional ingredients therefore, consumption and processing of this remarkable fruit must be encouraged as pharma food due to its antihyperlipidemic, antiviral, anti-inflammatory, antihyperglycemic, immunomodulatory, antihypertensive, antimicrobial and antioxidant potential, and these pharmacological properties of pumpkin are directly or indirectly related to the COVID 19 outbreak. Utilization of pumpkin has a domain in the form of powders, extracts, isolates, and pumpkin incorporated food products. A wide range of healthy, nutritious and functional food products has been developed from pumpkin, which includes juice, soup, porridge, chips, biscuits, bread, cake, bar and noodles. In recent times some innovative and novel technologies have been applied to process and preserve pumpkin for its enhanced shelf life and bioaccessibility of nutrients. Need of healthy eating in current post COVID 19 period is very crucial for healthy population, and medicinal foods like pumpkin, and bioactive compounds present in this functional food could play a vital role in developing a healthy community around the globe.

Recent developments in lactose blend formulations for carrier-based dry powder inhalation.

Lactose is the most commonly used excipient in carrier-based dry powder inhalation (DPI) formulations. Numerous inhalation therapies have been developed using lactose as a carrier material. Several theories have described the role of carriers in DPI formulations. Although these theories are valuable, each DPI formulation is unique and are not described by any single theory. For each new formulation, a specific development trajectory is required, and the versatility of lactose can be exploited to optimize each formulation. In this review, recent developments in lactose-based DPI formulations are discussed. The effects of varying the material properties of lactose carrier particles, such as particle size, shape, and morphology are reviewed. Owing to the complex interactions between the particles in a formulation, processing adhesive mixtures of lactose with the active ingredient is crucial. Therefore, blending and filling processes for DPI formulations are also reviewed. While the role of ternary agents, such as magnesium stearate, has increased, lactose remains the excipient of choice in carrier-based DPI formulations. Therefore, new developments in lactose-based DPI formulations are crucial in the optimization of inhalable medicine performance.

Empowering the Magersaren community: technology dissemination for ground coffee added value improvement

This paper is aimed to share the community service experiences held at Boro Sumbersari hamlet which is located at 98A UB forest plot. Boro Sumbersari hamlet is inhabited by Magersaren community. The Magersaren community are farmers and forest workers who depend on forest for their livelihoods. Magersaren has been practicing agroforestry for a long time. They grow Robusta and Arabica coffee among other forest plants. Currently coffee is a favorite beverage, the number of its consumers continues to increase. Many people are interested in the ground coffee beans made by Magersaren traditionally, but it has not been widely marketed. The purpose of this community service program is to generate an alternative source of Magersaren household income, through the added value improvement of local flavored ground coffee beans they have. The added value of magersaren's ground coffee beans can be increased through product development technologies such as attractive packaging techniques and the creation of new variants ground coffe beans by adding brown sugar and powdered ginger. The execution of community service activities that have been carried out consists of: (1) program socialization;(2) focus group discussion;(3) production, packaging and management training;(4) small-business starting up;(5) program evaluation. These community service activities are held during the social distancing due to the COVID-19 pandemic. This condition becomes an obstacle to the effectiveness of program implementation. The start-up small business needs to be continuously supported in order to survive through a critical period of business development, especially under economic pressure during the pandemic.

Different Doses, Forms, and Frequencies of Zinc Supplementation for the Prevention of Diarrhea and Promotion of Linear Growth among Young Bangladeshi Children: A Six-Arm, Randomized, Community-Based Efficacy Trial.

BACKGROUND: Children in resource-limited settings remain vulnerable to zinc deficiency and its consequences. OBJECTIVES: To evaluate the effects of different doses, durations, and frequencies of zinc supplementation on the incidence of diarrhea and change in linear growth among young children. METHODS: We conducted a randomized, partially double-blind, controlled, 6-arm, community-based efficacy trial in Dhaka, Bangladesh. Children aged 9-11 mo were randomly assigned to receive 1 of the following interventions for 24 wk: 1) standard micronutrient powder (MNP) containing 4.1 mg zinc and 10 mg iron, daily; 2) high-zinc (10 mg), low-iron (6 mg) (HiZn LoFe) MNP, daily; 3) HiZn (10 mg) LoFe (6 mg)/HiZn (10 mg), no-iron MNPs on alternating days; 4) dispersible zinc tablet (10 mg), daily; 5) dispersible zinc tablet (10 mg), daily for 2 wk at enrollment and 12 wk; 6) placebo powder, daily. Primary outcomes were incidence of diarrhea and change in length-for-age z-score (LAZ) over the 24-wk intervention period. Home visits were conducted twice weekly to assess diarrhea and other morbidity. Incidence and prevalence outcomes were compared among groups with Poisson regression; continuous outcomes were compared using ANCOVA. RESULTS: A total of 2886 children were enrolled between February 2018 and July 2019. The mean incidence and prevalence of diarrhea among all participants was 1.21 episodes per 100 d and 3.76 d per 100 d, respectively. There were no differences in the incidence or prevalence of diarrhea across intervention groups. The decline in LAZ was slightly smaller among children in the daily HiZn LoFe MNP group compared with the placebo powder group (P < 0.05). CONCLUSIONS: The dose of zinc in MNPs as well as the duration and frequency of supplementation evaluated in this trial were not effective in reducing diarrhea; however, the daily HiZn LoFe MNP formulation offered modest improvements in linear growth among young children. This trial was registered at clinicaltrials.gov as NCT03406793.

Acquisition of a Laser Powder Bed Fusion System to Transform the Additive Manufacturing Value Chain

Metal additive manufacturing (AM) has significant relevance to the missions of all branches of the Department of Defense (DoD) as it has the capability to bring parts to the warfighter more quickly and cost effectively However, DoD's goals of utilizing and deploying AM will not be achieved without substantial research and development to address the technology's current limitations, which exist at every facet of the AM value chain. The DURIP award, along with supplementary funding provided by Virginia Tech, enabled the acquisition of a reactive metal laser powder bed fusion (LPBF) AM system. The advanced AM system acquired through this program features open-access to all process parameters and features integrated in-situ monitoring technologies that enable research focused in increasing materials selection, creating new design for AM tools and methods, enhancing part quality through process-property-structure models, in-situ monitoring and post-processing techniques, and securing the platforms from cyber-physical vulnerabilities. The system is installed as a showcase piece in a newly created multidisciplinary educational and research space dedicated to preparing undergraduate and graduate students for future careers in Industry 4.0 technologies. As such, the new system will enable multi-disciplinary research and education across the entire value chain of AM.

Phi 6 Bacteriophage Inactivation by Metal Salts, Metal Powders, and Metal Surfaces.

The interaction of phages with abiotic environmental surfaces is usually an understudied field of phage ecology. In this study, we investigated the virucidal potential of different metal salts, metal and ceramic powders doped with Ag and Cu ions, and newly fabricated ceramic and metal surfaces against Phi6 bacteriophage. The new materials were fabricated by spark plasma sintering (SPS) and/or selective laser melting (SLM) techniques and had different surface free energies and infiltration features. We show that inactivation of Phi6 in solutions with Ag and Cu ions can be as effective as inactivation by pH, temperature, or UV. Adding powder to Ag and Cu ion solutions decreased their virucidal effect. The newly fabricated ceramic and metal surfaces showed very good virucidal activity. In particular, 45%TiO2 + 5%Ag + 45%ZrO2 + 5%Cu, in addition to virus adhesion, showed virucidal and infiltration properties. The results indicate that more than 99.99% of viruses deposited on the new ceramic surface were inactivated or irreversibly attached to it.

Perspective: Putting the youngest among us into the nutrition "call for action" for food fortification strategies.

Adequate iron intake is essential for optimal child development, but iron deficiency and anemia among infants and young children are widespread in low- and middle-income countries. Large-scale food fortification strategies hold great promise for reducing micronutrient deficiencies; however, for children <2 y of age, the impact of such strategies is limited because their intake of staple foods is relatively low and fortification levels are targeted at the adult population. Iron supplementation, iron fortification of foods targeted to infants, and point-of-use fortification with iron-containing products such as multiple micronutrient powders (MNPs) and small-quantity lipid-based nutrient supplements are evidence-based approaches recommended to reduce anemia among infants and young children when used in the right context. Since 2003, the WHO, with support from UNICEF, has recommended the use of MNPs to control iron deficiency. However, the percentage of children with anemia has changed very little over the past 10 y. Five years ago the UN declared a decade of action on nutrition, including World Health Assembly (WHA) targets for maternal, infant, and young child nutrition, yet the WHA set no anemia targets for children. In July 2020 the leaders of 4 UN agencies issued a call for action to protect children's right to nutrition in the face of the COVID-19 pandemic and beyond. Given persistently high rates of anemia among young children, the negative developmental impact, the challenge of meeting iron needs from typical complementary food diets, and the availability of successful evidence-based fortification strategies for this age group, we encourage planners, speakers, and donors at this year's UN Food Systems Summit and the Tokyo Nutrition for Growth Summit to 1) call for the WHA to set anemia targets for infants and young children and 2) promote investment in evidence-based interventions to improve the iron status of young children.

Novel and Evolving Therapies for COVID-19 Related Pulmonary Complications.

Coronaviruses disease 2019 (COVID-19) is the most crucial threat, the world has ever witnessed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of this disease pandemic. The World Health Organization has confirmed the continuing epidemic as a worldwide public health crisis. Presently, the research on COVID-19 is even in the primitive stage. Studies on unveiling the natural route of COVID-19 infection and related pathophysiology, the biology of pulmonary airways pose a more rational restorative approach in the management of COVID-19. Thus, based on the existing facts, we methodically reviewed the efforts put forth by various research institutes, pharmaceutical companies and biotechnology firms in pulmonary delivery to prevent and control the COVID-19. This article would be valuable for the healthcare community, which is efficiently dealing with the SARS-CoV-2 crisis.